gene

SGSH

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SGSH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

SGSH Gene

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🧬 Gene Info

Gene Symbol	SGSH
Full Name	N-Sulfoglucosamine Sulfohydrolase
Chromosome	17q25.3
Protein Type	Enzyme
Function	SGSH encodes sulfamidase (N-sulfoglucosamine sulfohydrolase), a lysosomal enzyme that catalyzes the removal of N-linked sulfate groups from heparan sulfate
UniProt ID	P51688
NCBI Gene ID	6448
Ensembl ID	ENSG00000138323
OMIM	605270
GeneCards	SGSH
Human Protein Atlas	SGSH
Substrate	N-sulfoglucosamine residues in heparan sulfate chains
Product	N-acetylglucosamine (or glucosamine) + sulfate
Optimal pH	~5.0 (lysosomal)
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SGSH — AlphaFold P51688 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SGSH Gene

gene · 606 words

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Pathway Diagram

graph TD
    SGSH["SGSH"]
    neurodegeneration["neurodegeneration"]
    SGSH -->|"implicated_in"| neurodegeneration
    style SGSH fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SGSH in their description or question text

No additional research found