Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SIRT1 insufficiency: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| metabolic failure | causes | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| H3: SIRT1 Insufficiency Disconnects Metabolic Sensing from E | 0.770 | neurodegeneration | Investigate mechanisms of epigenetic rep |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.770
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| SIRT1 and SIRT6: The role in aging-related diseases. [PMID:37499928] | You Y, Liang W | Biochim Biophys Acta Mol Basis | 2023 | 0 |
| SIRT1 and SIRT6: The role in aging-related diseases. [PMID:37499928] | You Y, Liang W | Biochimica et biophysica acta. | 2023 | 0 |
| Regulation of SIRT1 and Its Roles in Inflammation. [PMID:35359990] | Yang Y, Liu Y, Wang Y, Chao Y, Zhang J, | Frontiers in immunology | 2022 | 0 |
| SIRT1 and aging related signaling pathways. [PMID:32084459] | Chen C, Zhou M, Ge Y, Wang X | Mechanisms of ageing and devel | 2020 | 0 |
| NAD(+) metabolism governs the proinflammatory senescence-associated secretome. [PMID:30778219] | Unknown | Nat Cell Biol | 2019 | 0 |
| Sirt1 and the Mitochondria. [PMID:26831453] | Tang BL | Molecules and cells | 2016 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning SIRT1 insufficiency in their description or question text
No additional research found