SIRT3

protein-coding External Resolution
GeneCards NCBI PubMed

External Info (via mygene)

SymbolSIRT3
Namesirtuin 3
Typeprotein-coding
Sourcemygene

Summary

SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019].

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