gene

SIVA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIVA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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Summary

SIVA1 gene - pro-apoptotic protein involved in CD27 signaling, apoptosis regulation, and neuronal cell death in neurodegenerative diseases including Alzheimer's and Parkinson's

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🧬 Gene Info

Gene Symbol	SIVA1
Full Name	SIVA Apoptosis-Inducing Factor
Aliases	SIVA, CD27BP, SIVA-1
Chromosome	14q32.33
Function	Pro-apoptotic signaling, CD27 interaction, caspase activation
Primary Expression	most human tissues with notable levels in: - Brain: Cerebral cortex, hippocampus, cerebellum, basal ganglia - Lymphoid organs: Spleen, thymus
Subcellular Localization	and function[@yang2000]
Amino Acids	175 aa
Exons	4
UniProt ID	O15304
NCBI Gene ID	8487
Ensembl ID	ENSG00000184117
GeneCards	SIVA1
Human Protein Atlas	SIVA1
Protein Length	175 aa
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SIVA1 — AlphaFold O15304 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SIVA1 — SIVA Apoptosis-Inducing Factor

gene · 2866 words

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Genes

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Pathway Diagram

graph TD
    SIVA1["SIVA1"]
    neurodegeneration["neurodegeneration"]
    SIVA1 -->|"implicated_in"| neurodegeneration
    style SIVA1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity