Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SIX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SIX1 |
| Full Name | SIX Homeobox 1 |
| Chromosome | 14q23.1 |
| Protein Type | Transcription Factor |
| Function | SIX1 is a transcription factor with multiple roles |
| Primary Expression | the adult brain where it contributes to neuronal function and may be implicated in neurodegeneration |
| UniProt ID | Q9H2Y9 |
| NCBI Gene ID | 6495 |
| Ensembl ID | ENSG00000126778 |
| OMIM | 601205 |
| GeneCards | SIX1 |
| Human Protein Atlas | SIX1 |
| Associated Diseases | Branchio-otic Syndrome, Neurodegeneration (potential role) |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SIX1["SIX1"]
neurodegeneration["neurodegeneration"]
SIX1 -->|"implicated_in"| neurodegeneration
style SIX1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||