gene

SLC11A2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SLC11A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for SLC11A2 Gene

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🧬 Gene Info

Gene Symbol	SLC11A2
Full Name	Solute Carrier Family 11 Member 2 (Divalent Metal Transporter 1, DMT1)
Chromosome	12q13.12
Protein Type	Transporter
Function	Divalent metal ion transport
Primary Expression	Duodenum, Brain, Kidney, Bone marrow
Amino Acids	561 aa
UniProt ID	P49281
NCBI Gene ID	4891
Ensembl ID	ENSG00000124317
GeneCards	SLC11A2
Human Protein Atlas	SLC11A2
Intestinal absorption	Mediates Fe2+ uptake from the gut lumen into duodenal enterocytes
Iron recycling	Facilitates iron release from macrophages during erythrocyte recycling
Transferrin-independent uptake	Provides an alternative pathway for cellular iron acquisition
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC11A2 — AlphaFold P49281 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC11A2 Gene

gene · 931 words

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Pathway Diagram

graph TD
    SLC11A2["SLC11A2"]
    neurodegeneration["neurodegeneration"]
    SLC11A2 -->|"implicated_in"| neurodegeneration
    style SLC11A2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC11A2 in their description or question text

No additional research found