Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC12A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SLC12A1 (Solute Carrier Family 12 Member 1 / NKCC2) - renal sodium-potassium-2 chloride transporter, essential for kidney function, implicated in Bartter syndrome and potential neurological roles through fluid balance
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| Gene Symbol | SLC12A1 |
| Full Name | Solute Carrier Family 12 Member 1 |
| Aliases | Solute Carrier Family 12 Member 1 / NKCC2 |
| Chromosome | 15q21.1 |
| Primary Expression | the thick ascending limb (TAL) of the loop of Henle in the kidney, where it plays a critical role in renal tubular salt reabsorption and the maintenan |
| Molecular Weight | 130 kDa |
| Amino Acids | 1219 aa |
| UniProt ID | P55011 |
| NCBI Gene ID | 6557 |
| Ensembl ID | ENSG00000043355 |
| OMIM | 241200 |
| GeneCards | SLC12A1 |
| Human Protein Atlas | SLC12A1 |
| 12 transmembrane domains | Characteristic of the SLC12A family |
| Intracellular N-terminus | Contains regulatory domains |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SLC12A1["SLC12A1"]
neurodegeneration["neurodegeneration"]
SLC12A1 -->|"implicated_in"| neurodegeneration
style SLC12A1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SLC12A1 in their description or question text
No additional research found