Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC15A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SLC15A2 |
| Full Name | Solute Carrier Family 15 Member 2 (Peptide Transporter 2) |
| Aliases | Peptide Transporter 2 |
| Chromosome | 3q27 |
| Protein Type | Transporter |
| Function | Unlike its paralog SLC15A1 (PEPT1), which is expressed in intestinal epithelium, SLC15A2 exhibits higher affinity for peptides and is primarily expressed in renal proximal tubules and the brain[@brand |
| Primary Expression | kidney and brain |
| Subcellular Localization | the apical membrane of epithelial cells, where it functions as an uptake transporter for peptide reabsorption[@tamai2004 |
| UniProt ID | O75374 |
| NCBI Gene ID | 6565 |
| Ensembl ID | ENSG00000065427 |
| OMIM | 607456 |
| GeneCards | SLC15A2 |
| Human Protein Atlas | SLC15A2 |
| Kidney | High expression in proximal tubules — primary site for peptide reabsorption |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SLC15A2["SLC15A2"]
neurodegeneration["neurodegeneration"]
SLC15A2 -->|"implicated_in"| neurodegeneration
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SLC15A2 in their description or question text
No additional research found