Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC17A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Gene profile: SLC17A1/VGLUT1 - the primary vesicular glutamate transporter that packages glutamate into synaptic vesicles for excitatory neurotransmission
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| Gene Symbol | SLC17A1 |
| Full Name | Soluble Carrier Family 17 Member 1 (VGLUT1) |
| Aliases | Gene profile: SLC17A1/VGLUT1 |
| Chromosome | 6p21.3 |
| Protein Type | Transporter |
| Function | It functions as an electrogenic antiporter that transports glutamate into synaptic vesicles in exchange for protons (H+) that are pumped into the vesicle by the V-ATPase. |
| UniProt ID | O15230 |
| NCBI Gene ID | 6568 |
| Ensembl ID | ENSG00000139508 |
| OMIM | 182002 |
| GeneCards | SLC17A1 |
| Human Protein Atlas | SLC17A1 |
| NMDA receptors | Ionotropic, high conductance, Ca²⁺-permeable |
| AMPA receptors | Ionotropic, fast excitatory responses |
| Kainate receptors | Ionotropic, modulatory effects |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SLC17A1["SLC17A1"]
neurodegeneration["neurodegeneration"]
SLC17A1 -->|"implicated_in"| neurodegeneration
style SLC17A1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SLC17A1 in their description or question text
No additional research found