Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about slc17a8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SLC17A8 |
| Function | SLC17A8 encodes vesicular glutamate transporter 3 (VGLUT3), responsible for packaging glutamate into synaptic vesicles in neurons. |
| Primary Expression | glutamatergic neurons, VGLUT3 has a unique expression pattern in monoaminergic and cholinergic neurons, where it packages glutamate as a cotransmitter |
| Ensembl ID | ENSG00000179520 |
| GeneCards | SLC17A8 |
| Human Protein Atlas | SLC17A8 |
| Preserved Outer Hair Cell Function | Unlike typical sensorineural hearing loss, auditory neuropathy shows normal otoacoustic emissions (OAEs) and preserved cochlear microphonic responses, indicating intact outer hair cell function. |
| Abnormal Neural Responses | Absent or abnormal auditory brainstem responses (ABRs) indicate disrupted neural transmission from the inner hair cell-synapse to the auditory brainstem. |
| Speech Perception Deficits | Despite preserved hair cell function, patients with auditory neuropathy have severe difficulties with speech perception, particularly in noisy environments. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["slc17a8 gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:SLC17A8 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:SLC17A8 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning slc17a8 in their description or question text
No additional research found