gene

SLC18A1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SLC18A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Vesicular transporter for monoamines

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🧬 Gene Info

Gene Symbol	SLC18A1
Full Name	Solute Carrier Family 18 Member 1
Chromosome	8p21.3
Protein Type	Transporter
Function	Dopamine: Critical for reward and movement
Primary Expression	Substantia Nigra, Locus Coeruleus, Adrenal Medulla
Amino Acids	525 aa
UniProt ID	P54219
NCBI Gene ID	6570
GeneCards	SLC18A1
Human Protein Atlas	SLC18A1
Proton gradient	V-ATPase pumps H+ into vesicles
Substrate binding	Monoamines bind to VMAT1
Exchange	H+ exits, monoamine enters
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC18A1 — AlphaFold P54219 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC18A1 Gene

gene · 578 words

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Pathway Diagram

graph TD
    SLC18A1["SLC18A1"]
    neurodegeneration["neurodegeneration"]
    SLC18A1 -->|"implicated_in"| neurodegeneration
    style SLC18A1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SLC18A1 in their description or question text

No additional research found