gene

SLC1A4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC1A4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Solute Carrier Family 1 Member 4 (Serine Transporter) gene

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🧬 Gene Info

Gene Symbol	SLC1A4
Aliases	Serine Transporter
Chromosome	2p15
Protein Type	Gene
Function	is a sodium-dependent neutral amino acid transporter that plays critical roles in neuronal development, brain metabolism, and cellular homeostasis[@amino2017][@slc2020].
Primary Expression	astrocytes, where it plays a critical role in astrocyte-neuron metabolic coupling[@glia2018]
Amino Acids	554 aa
UniProt ID	P47821
NCBI Gene ID	6509
Ensembl ID	ENSG00000135506
OMIM	600235
GeneCards	SLC1A4
Human Protein Atlas	SLC1A4
Protein Name	ASCT1 (Alanine, Serine, Cysteine Transporter 1)
N-terminal extracellular domain	Involved in substrate recognition
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC1A4 — AlphaFold P47821 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC1A4 Gene

gene · 1807 words

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Pathway Diagram

graph TD
    SLC1A4["SLC1A4"]
    neurodegeneration["neurodegeneration"]
    SLC1A4 -->|"implicated_in"| neurodegeneration
    style SLC1A4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SLC1A4 in their description or question text

No additional research found