Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC22A3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive overview of OCT3 (organic cation transporter 3), its role in monoamine clearance, and implications for Alzheimer's Disease, Parkinson's Disease, and neuropsychiatric disorders.
| Gene Symbol | SLC22A3 |
| Full Name | Solute Carrier Family 22 Member 3 (OCT3) |
| Aliases | organic cation transporter 3 |
| Chromosome | 6q27 |
| Protein Type | Transporter |
| Function | is a polyspecific transmembrane transporter encoded by the SLC22A3 gene on chromosome 6q27[@koepsell2007]. |
| Primary Expression | multiple tissues throughout the body: |
| Amino Acids | 556 aa |
| Exons | 11 |
| UniProt ID | O75727 |
| NCBI Gene ID | 6581 |
| Ensembl ID | ENSG00000149402 |
| OMIM | 604349 |
| GeneCards | SLC22A3 |
| Human Protein Atlas | SLC22A3 |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["SLC22A3"]
N1["ASTROCYTES"]
N1 -->|"regulates"| N0
N2["neurodegeneration"]
N0 -->|"implicated in"| N2
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 gene| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| ASTROCYTES | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||