Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC39A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive information about SLC39A1 (ZIP1), a zinc transporter critical for neuronal zinc homeostasis, synaptic function, and implicated in Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.
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| Gene Symbol | SLC39A1 |
| Full Name | Solute Carrier Family 39 Member 1 (ZIP1 Transporter) |
| Chromosome | 1q21.3 |
| Protein Type | Transporter |
| Function | is a member of the ZIP (Zrt-, Irt-like Protein) family of metal transporters, which play essential roles in maintaining cellular zinc homeostasis. |
| Subcellular Localization | both presynaptic terminals and postsynaptic dendritic spines, positioning it to regulate synaptic zinc levels during neu |
| Molecular Weight | 54 kDa |
| Amino Acids | 477 aa |
| Exons | 12 |
| UniProt ID | [Q9Y5L4](https://www.uniprot.org/uniprot/Q9Y5L4) |
| Ensembl ID | ENSG00000143570 |
| GeneCards | SLC39A1 |
| Human Protein Atlas | SLC39A1 |
| Brain | High expression in cortex, hippocampus, cerebellum, and basal ganglia |
| Neurons | Enriched in excitatory neurons, particularly in dendritic compartments |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SLC39A1["SLC39A1"]
neurodegeneration["neurodegeneration"]
SLC39A1 -->|"implicated_in"| neurodegeneration
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SLC39A1 in their description or question text
No additional research found