gene

SLC39A14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC39A14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

SLC39A14 encodes a zinc and manganese transporter with critical roles in metal homeostasis. Mutations cause manganese metabolism disorders with parkinsonian features, and dysregulation contributes to metal-induced neurotoxicity in Parkinson's disease and other neurodegenerative conditions.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	SLC39A14
Full Name	Solute Carrier Family 39 Member 14 (Zip14)
Chromosome	8p22
Protein Type	Transporter
Function	is a membrane transporter that facilitates the uptake of zinc and manganese into cells.
Amino Acids	648 aa
UniProt ID	[Q5HYNY4](https://www.uniprot.org/uniprot/Q5HYNY4)
Ensembl ID	ENSG00000146373
GeneCards	SLC39A14
Human Protein Atlas	SLC39A14
Length	648 amino acids
Topology	8 transmembrane domains
N-terminus	Extracellular with potential metal-binding sites
C-terminus	Intracellular with regulatory motifs
Conserved motifs	H-XHXH and H-X4-H in transmembrane domains for metal binding
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SLC39A14 — Solute Carrier Family 39 Member 14 (Zip14)

gene · 1577 words

→

SLC39A14 Protein

protein · 613 words

→

Pathway Diagram

graph TD
    SLC39A14["SLC39A14"]
    neurodegeneration["neurodegeneration"]
    SLC39A14 -->|"implicated in"| neurodegeneration
    Neurodegenerative_Conditions{"Neurodegenerative Conditions"}
    SLC39A14 -->|"implicated in"| Neurodegenerative_Conditions
    Parkinson{"Parkinson"}
    SLC39A14 -->|"implicated in"| Parkinson
    Parkinson_S_Disease{"Parkinson'S Disease"}
    SLC39A14 -->|"implicated in"| Parkinson_S_Disease
    style SLC39A14 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Parkinson fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Parkinson_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Neurodegenerative_Conditions fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC39A14 in their description or question text

No additional research found