gene

SLC39A4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC39A4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	SLC39A4
Full Name	Solute Carrier Family 39 Member 4
Chromosome	8q21.3
Protein Type	Transporter
Function	is an essential trace element fundamental to numerous biological processes, including enzyme function, gene expression, immune response, and neurological signaling.
Primary Expression	pancreatic acinar cells, contributing to zinc secretion in digestive fluids
Amino Acids	647 aa
UniProt ID	[Q9NPF7](https://www.uniprot.org/uniprot/Q9NPF7)
Ensembl ID	ENSG00000147894
GeneCards	SLC39A4
Human Protein Atlas	SLC39A4
Eight transmembrane domains	The protein contains eight predicted transmembrane helices that span the plasma membrane, creating a channel through which zinc ions are transported[@moynie2019].
N-linked glycosylation sites	The extracellular loops contain asparagine-linked glycosylation motifs that are important for proper protein folding, trafficking to the plasma membrane, and stability[@valenzano2011].
Dimetric arrangement	Functional ZIP4 likely operates as a homodimer, with each monomer capable of forming an independent transport pathway. This dimeric structure is conserved among ZIP family members.
Intestine	Highest expression in the apical membrane of enterocytes in the small intestine, where it mediates dietary zinc absorption[@wang2004].
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SLC39A4["SLC39A4"]
    neurodegeneration["neurodegeneration"]
    SLC39A4 -->|"implicated_in"| neurodegeneration
    style SLC39A4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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No papers found