gene

SLC39A6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC39A6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

SLC39A6 (ZIP6) is a zinc transporter critical for cellular zinc homeostasis. Dysregulated zinc transport is implicated in Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions.

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🧬 Gene Info

Gene Symbol	SLC39A6
Full Name	Solute Carrier Family 39 Member 6
Chromosome	18q12.3
Protein Family	ZIP (Zrt-, Irt-like Protein) transporter family
Protein Type	Transporter
Function	encodes a zinc transporter protein belonging to the ZIP (Zrt-, Irt-like Protein) family, a group of proteins critical for cellular zinc homeostasis.
Amino Acids	647 aa
UniProt ID	Q9GZP8
NCBI Gene ID	201131
Ensembl ID	ENSG00000141431
OMIM	607337
GeneCards	SLC39A6
Human Protein Atlas	SLC39A6
Common Aliases	ZIP6, LIV-1
Protein Length	647 amino acids
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC39A6 — AlphaFold Q9GZP8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SLC39A6["SLC39A6"]
    neurodegeneration["neurodegeneration"]
    SLC39A6 -->|"implicated_in"| neurodegeneration
    style SLC39A6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found