gene

SLC5A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC5A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for SLC5A1 (Sodium/Glucose Cotransporter 1)

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	SLC5A1
Aliases	Sodium/Glucose Cotransporter 1
Protein Type	Transporter
Function	SLC5A1 serves multiple physiological functions
Primary Expression	the brain and may play roles in cerebral glucose metabolism relevant to neurodegenerative diseases
Amino Acids	664 aa
UniProt ID	[P13866](https://www.uniprot.org/uniprot/P13866)
NCBI Gene ID	6523
GeneCards	SLC5A1
Human Protein Atlas	SLC5A1
Cerebral Glucose Hypometabolism	AD is characterized by reduced brain glucose utilization, and SGLT1 upregulation may represent a compensatory mechanism.[@an2018]
Blood-Brain Barrier	SGLT1 at the BBB may help maintain glucose supply when glucose levels are low.[@nizari2019]
Neuronal Vulnerability	Hippocampal neurons expressing SGLT1 may have enhanced survival during metabolic stress.[@yu2010]
SGLT Inhibitors	Pharmacological SGLT1 inhibition may worsen or improve AD depending on context and dosing.[@wiciski2020]
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC5A1 (Sodium/Glucose Cotransporter 1)

gene · 1014 words

→

Pathway Diagram

graph TD
    SLC5A1["SLC5A1"]
    neurodegeneration["neurodegeneration"]
    SLC5A1 -->|"implicated_in"| neurodegeneration
    style SLC5A1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC5A1 in their description or question text

No additional research found