gene

SLC6A11

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SLC6A11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	SLC6A11
Full Name	Solute Carrier Family 6 Member 11 (GABA Transporter 3, GAT3)
Chromosome	3p25.3
Function	encodes a critical membrane transport protein responsible for the uptake of gamma-aminobutyric acid (GABA) from the extracellular space.
Primary Expression	astrocytes throughout the central nervous system, where it plays an essential role in terminating GABAergic signaling, maintaining neurotransmitter ho
Molecular Weight	61 kDa
Amino Acids	559 aa
UniProt ID	P31391
NCBI Gene ID	6404
Ensembl ID	ENSG00000111046
OMIM	137180
GeneCards	SLC6A11
Human Protein Atlas	SLC6A11
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC6A11 — AlphaFold P31391 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC6A11 Gene

gene · 2112 words

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Pathway Diagram

graph TD
    SLC6A11["SLC6A11"]
    neurodegeneration["neurodegeneration"]
    SLC6A11 -->|"implicated_in"| neurodegeneration
    style SLC6A11 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SLC6A11 in their description or question text

No additional research found