Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC6A11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SLC6A11 |
| Full Name | Solute Carrier Family 6 Member 11 (GABA Transporter 3, GAT3) |
| Chromosome | 3p25.3 |
| Function | encodes a critical membrane transport protein responsible for the uptake of gamma-aminobutyric acid (GABA) from the extracellular space. |
| Primary Expression | astrocytes throughout the central nervous system, where it plays an essential role in terminating GABAergic signaling, maintaining neurotransmitter ho |
| Molecular Weight | ~61 kDa |
| Amino Acids | 559 aa |
| UniProt ID | P31391 |
| NCBI Gene ID | 6404 |
| Ensembl ID | ENSG00000111046 |
| OMIM | 137180 |
| GeneCards | SLC6A11 |
| Human Protein Atlas | SLC6A11 |
| Protein Length | 559 amino acids |
| GABA | Highest |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SLC6A11["SLC6A11"]
neurodegeneration["neurodegeneration"]
SLC6A11 -->|"implicated_in"| neurodegeneration
style SLC6A11 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||