gene

SLC6A8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC6A8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Solute Carrier Family 6 Member 8 (Creatine Transporter) gene

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🧬 Gene Info

Gene Symbol	SLC6A8
Aliases	Creatine Transporter
Chromosome	Xq28
Function	encodes an 11-transmembrane-domain protein of approximately 635 amino acids.
Primary Expression	most tissues, with particularly high expression in kidney, brain, muscle, and heart
Amino Acids	635 aa
GeneCards	SLC6A8
Human Protein Atlas	SLC6A8
N-terminal intracellular domain	Contains regulatory serine residues subject to phosphorylation
Transmembrane core	Forms the substrate-binding site (S1) and the gate mechanism
Large extracellular loop 1	Contains glycosylation sites important for surface expression
C-terminal intracellular tail	Contains PDZ-binding motif for scaffolding protein interaction
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC6A8 Gene

gene · 1511 words

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Pathway Diagram

graph TD
    SLC6A8["SLC6A8"]
    neurodegeneration["neurodegeneration"]
    SLC6A8 -->|"implicated_in"| neurodegeneration
    style SLC6A8 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SLC6A8 in their description or question text

No additional research found