gene

SLC6A9

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SLC6A9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Solute Carrier Family 6 Member 9 (Glycine Transporter 2) gene

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🧬 Gene Info

Gene Symbol	SLC6A9
Aliases	Glycine Transporter 2
Chromosome	1p34.1
Function	The SLC6A9 locus is on chromosome 1p34.1 and encodes a 12-transmembrane-domain protein of approximately 638 amino acids.
Primary Expression	presynaptic terminals of glycinergic neurons in the brainstem and spinal cord
Amino Acids	638 aa
GeneCards	SLC6A9
Human Protein Atlas	SLC6A9
N-terminal intracellular domain	Contains regulatory serine residues and motifs for interaction with scaffolding proteins
Transmembrane core	Forms the substrate-binding pocket (S1 site) with high affinity for glycine
Extracellular loops	Heavily glycosylated at conserved NXT motifs
C-terminal intracellular tail	Contains a PDZ-binding motif (Ser-Ser-Leu) for interaction with gephyrin and other synaptic scaffold proteins
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC6A9 Gene

gene · 1274 words

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Pathway Diagram

graph TD
    SLC6A9["SLC6A9"]
    neurodegeneration["neurodegeneration"]
    SLC6A9 -->|"implicated_in"| neurodegeneration
    style SLC6A9 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SLC6A9 in their description or question text

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