Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SMAD5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SMAD5 is a receptor-regulated SMAD (R-SMAD) that mediates BMP signaling. Critical roles in neurogenesis, synaptic plasticity, and neurodegenerative disease pathogenesis.
No AI portrait yet
| Gene Symbol | SMAD5 |
| Full Name | SMAD Family Member 5 |
| Aliases | R-SMAD |
| Chromosome | 5q31.1 |
| Protein Type | Receptor |
| Function | is a critical signal transduction protein that functions as a receptor-regulated SMAD (R-SMAD) in the bone morphogenetic protein (BMP) signaling pathway. |
| Molecular Weight | 52 kDa |
| Amino Acids | 465 aa |
| Exons | 9 |
| Pathways | TGF-β Signaling |
| UniProt ID | Q99717 |
| NCBI Gene ID | 4090 |
| Ensembl ID | ENSG00000113657 |
| OMIM | 603109 |
| GeneCards | SMAD5 |
| Human Protein Atlas | SMAD5 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SMAD5["SMAD5"]
neurodegeneration["neurodegeneration"]
SMAD5 -->|"implicated_in"| neurodegeneration
style SMAD5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SMAD5 in their description or question text
No additional research found