Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SMARCAL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SMARCAL1 |
| Full Name | SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator of Chromatin Subfamily A-Like Protein 1 |
| Aliases | HARP, MARCAL1 |
| Chromosome | 2q35 |
| Function | encodes an ATP-dependent annealing helicase that remodels stalled DNA replication forks and stabilizes genomic integrity. |
| Gene Type | Protein-coding |
| UniProt ID | Q9NZC9 |
| Ensembl ID | ENSG00000138375 |
| OMIM | 606622 |
| GeneCards | SMARCAL1 |
| Human Protein Atlas | SMARCAL1 |
| HGNC | 11102 |
| Entrez Gene | 50485 |
| R17 | Nonsense |
| R561H | Missense |
| Associated Diseases | neurodegeneration |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
SMARCAL1(["SMARCAL1"])
DNA_damage("DNA damage")
cGAS_STING_signaling["cGAS-STING signaling"]
PD_L1(["PD-L1"])
anti_tumor_immune_response("anti-tumor immune response")
neurodegeneration["neurodegeneration"]
SMARCAL1 -.->|"inhibits"| DNA_damage
SMARCAL1 -.->|"inhibits"| cGAS_STING_signaling
SMARCAL1 -->|"promotes"| PD_L1
SMARCAL1 -.->|"inhibits"| anti_tumor_immune_response
SMARCAL1 -->|"implicated in"| neurodegeneration
style SMARCAL1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| DNA damage | inhibits | process | 0.95 |
| cGAS-STING signaling | inhibits | pathway | 0.95 |
| anti-tumor immune response | inhibits | process | 0.90 |
| PD-L1 | promotes | protein | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||