Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SOD1, HTT, TARDBP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | associated_with | disease | 0.50 |
| SOD1, TARDBP, BDNF, GDNF, IGF-1 | co_associated_with | gene | 0.40 |
| UBE3A, PARK2, PINK1 | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MSH3, PMS1 | co_associated_with | gene | 0.40 |
| MT-ND1, MT-ND4, MT-ND6 | co_associated_with | gene | 0.40 |
| APOE | co_associated_with | gene | 0.40 |
| SIRT1, FOXO3, NRF2, TFAM | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo | 0.465 | neurodegeneration | CRISPR-based therapeutic approaches for |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable S [PMID:34586830] | Picó S, Parras A, Santos-Galindo M, Pose | Sci Transl Med | 2021 | 0 |