Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SPECT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson's Disease | biomarker_for | disease | 0.85 |
| MOLECULAR_IMAGING | regulates | phenotype | 0.72 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| MAPT tau seeding and release across AD, FTD, and PD-spectrum | 0.812 | multi | Cross-disease neurodegeneration mechanis |
| GRN/progranulin lysosomal insufficiency across FTD, ALS-spec | 0.756 | multi | Cross-disease neurodegeneration mechanis |
| Stathmin-2 Splice Switching to Prevent Axonal Degeneration A | 0.664 | neurodegeneration | RNA binding protein dysregulation across |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663] | Krasemann S, Madore C, Cialic R, Baufeld | Immunity | 2017 | 1 |
| LRRK2 Promotes Tau Accumulation, Aggregation and Release. [PMID:26014385] | Unknown | Molecular neurobiology | 2017 | 0 |
| Etiology and pathophysiology of frontotemporal dementia, Parkinson disease and A [PMID:18322368] | Unknown | Neuro-degenerative diseases | 2008 | 0 |
| Mutations in progranulin cause tau-negative frontotemporal dementia linked to ch [PMID:16862116] | Unknown | Nature | 2006 | 0 |
| Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia l [PMID:16862115] | Unknown | Nature | 2006 | 0 |
| The role of tau (MAPT) in frontotemporal dementia and related tauopathies. [PMID:15365985] | Unknown | Human mutation | 2005 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SPECT in their description or question text
No additional research found