gene

STAM1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about STAM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Gene page for STAM1 (signal transducing adaptor molecule 1) - novel Parkinson's disease therapeutic target involved in endolysosomal pathway

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🧬 Gene Info

Gene Symbol	STAM1
Full Name	Signal Transducing Adaptor Molecule 1
Chromosome	10p13
Function	is a key component of the endolysosomal pathway that has been recently identified as a novel Parkinson's disease therapeutic target[@stam1_pd_2024].
Primary Expression	Ubiquitous, high in brain
Molecular Weight	56 kDa
Amino Acids	425 aa
GeneCards	STAM1
Human Protein Atlas	STAM1
UIM (Ubiquitin-Interacting Motif)	binds ubiquitin-tagged proteins
VHS domain	cargo sorting
SH3 domain	protein-protein interactions
ITAM motif	signaling functions
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

STAM1 - Signal Transducing Adaptor Molecule 1

gene · 559 words

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Pathway Diagram

graph TD
    STAM1["STAM1"]
    neurodegeneration["neurodegeneration"]
    STAM1 -->|"implicated_in"| neurodegeneration
    style STAM1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning STAM1 in their description or question text

No additional research found