Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STK24: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | STK24 |
| Chromosome | 13q12.11 |
| Protein Type | Serine/Threonine Kinase |
| Function | is a member of the Ste20 family of serine/threonine kinases. |
| Primary Expression | the brain and has been increasingly recognized for its involvement in neurodegenerative diseases, particularly Alzheimer's disease (AD) and Parkinson' |
| Amino Acids | 462 aa |
| Exons | 12 |
| Pathways | MAPK Signaling, MAPK, MAPK pathway, PI3K, NF-κB |
| GeneCards | STK24 |
| Human Protein Atlas | STK24 |
| N-terminal Kinase Domain | Catalytic domain responsible for ATP binding and phosphoryl transfer (residues 1-280) |
| Coiled-coil Region | Mediates protein-protein interactions and dimerization (residues 281-350) |
| C-terminal Regulatory Domain | Contains autophosphorylation sites that regulate kinase activity (residues 351-462) |
| Synaptic Plasticity | Regulates dendritic spine morphology and synaptic strength through modulation of actin cytoskeleton dynamics [6] |
| Axon Guidance | Controls growth cone collapse and axon pathfinding through semaphorin signaling |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
STK24["STK24"]
neurodegeneration["neurodegeneration"]
STK24 -->|"implicated_in"| neurodegeneration
style STK24 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning STK24 in their description or question text
No additional research found