gene

STX5

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about STX5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

STX5 (Syntaxin 5) - a Golgi-localized SNARE protein essential for ER-Golgi trafficking, implicated in Alzheimer's disease and Parkinson's disease

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🧬 Gene Info

Gene Symbol	STX5
Full Name	Syntaxin 5
Chromosome	11q12.1
Function	is a member of the syntaxin family of SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) proteins that plays a critical role in intracellular membrane trafficking.
Subcellular Localization	Syntaxin 5 is primarily localized to:
Amino Acids	355 aa
UniProt ID	[P49005](https://www.uniprot.org/uniprot/P49005)
Ensembl ID	ENSG00000162353
GeneCards	STX5
Human Protein Atlas	STX5
Golgi apparatus	cis-Golgi network and medial Golgi
Endoplasmic reticulum	ER exit sites
Vesicular transport intermediates	COPII and COPI vesicles
Syntaxin 5 + Ykt6 + GS28 + Membrin	ER-Golgi transport
Syntaxin 5 + GOSR1 + Bet1	Intra-Golgi transport
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

STX5 Gene

gene · 989 words

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Pathway Diagram

graph TD
    STX5["STX5"]
    neurodegeneration["neurodegeneration"]
    STX5 -->|"implicated_in"| neurodegeneration
    style STX5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning STX5 in their description or question text

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