gene

SV2B

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SV2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for SV2B Gene

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🧬 Gene Info

Gene Symbol	SV2B
Full Name	Synaptic Vesicle Glycoprotein 2B
Chromosome	15q21.2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	all synaptic vesicles
Amino Acids	600 aa
UniProt ID	[Q9H0Y5](https://www.uniprot.org/uniprot/Q9H0Y5)
Ensembl ID	ENSG00000122012
GeneCards	SV2B
Human Protein Atlas	SV2B
Single transmembrane helix	Anchors the protein in synaptic vesicle membrane
SV2A	Ubiquitously expressed in all synaptic vesicles
SV2B	Brain-specific, primarily in excitatory synapses
SV2C	Basal ganglia-enriched expression
Synaptotagmin-1	Calcium sensor for exocytosis
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SV2B Gene

gene · 1074 words

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Pathway Diagram

graph TD
    SV2B["SV2B"]
    neurodegeneration["neurodegeneration"]
    SV2B -->|"implicated_in"| neurodegeneration
    style SV2B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SV2B in their description or question text

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