protein

SYPTEST

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SYPTEST: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	SYPTEST
Full Name	Synaptophysin Test
Chromosome	Xp11.23
Protein Type	Protein
Function	is a major synaptic vesicle protein and widely used neuronal marker in neurobiology and neurodegenerative disease research.
Subcellular Localization	to synaptic vesicles, synaptophysin is extensively used as a immunohistochemical
UniProt ID	Search UniProt
GeneCards	SYPTEST
Human Protein Atlas	SYPTEST
Synaptic loss in AD	Masliah et al. demonstrated significant reduction in synaptophysin immunoreactivity in AD hippocampus, correlating with memory deficits [3].
Biomarker potential	CSF synaptophysin levels are being investigated as a biomarker for synaptic degeneration in AD [4].
Relationship to amyloid	Synaptic dysfunction induced by amyloid-beta oligomers includes alterations in synaptophysin expression and distribution [5].
Lewy body dementia	Synaptophysin loss in cortical regions correlates with cognitive symptoms
Frontotemporal dementia	Reduced synaptophysin in frontal and temporal cortices
Huntington's disease	Early synaptic alterations include synaptophysin changes
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SYPTEST — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Synaptophysin Test

protein · 873 words

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Pathway Diagram

graph TD
    SYPTEST["SYPTEST"]
    neurodegeneration["neurodegeneration"]
    SYPTEST -->|"implicated_in"| neurodegeneration
    style SYPTEST fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

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Experiments (0)

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Related Research

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