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entity

Senataxin / R-loop resolution / DNA-RNA hybrid

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Senataxin / R-loop resolution / DNA-RNA hybrid: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections
1Hypotheses
1Analyses
0Outgoing
1Incoming
10Experiments

Outgoing (0)

TargetRelationTypeStr
No outgoing edges

Incoming (1)

SourceRelationTypeStr
SETXparticipates_ingene0.43

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
R-Loop Resolution Enhancement Therapy 0.428 neurodegeneration RNA binding protein dysregulation across

Mentioning Analyses (1)

Scientific analyses that reference this entity

RNA binding protein dysregulation across ALS FTD and AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.490

Experiments (10)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts clinical ALS 0.400 0.50 human proposed $6,550,000
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD validation ALS 0.400 0.50 human proposed $2,730,000
Environmental Exposure Causal Attribution in ALS — Experiment Design validation ALS 0.400 0.50 human proposed $3,000,000
Progranulin Replacement Therapy for FTD — Vector Development and Valid clinical ALS 0.400 0.50 human proposed $5,460,000
ALS Progression Rate Heterogeneity — mechanism and biomarker predictor clinical ALS 0.400 0.50 human proposed $6,550,000
TDP-43 PET Ligand Development for FTD and ALS clinical ALS 0.400 0.50 human proposed $6,550,000
FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutation Carriers validation ALS 0.400 0.50 human proposed $3,000,000
Frontal and Temporal Lobe Selective Vulnerability in FTD — Mechanisms validation Neurodegeneration 0.400 0.50 human proposed $3,000,000
DNA Damage Repair Deficiency Validation Study in Parkinson's Disease clinical Parkinson's Disease 0.400 0.50 human proposed $7,500,000
ALS Regional Onset and Spread: Network-Level Staging Model clinical ALS 0.400 0.50 human proposed $7,500,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Allele-specific silencing of a dominant SETX mutation in familial amyotrophic la [PMID:40200577] Winkelsas A, Apfel A, Johnson B, Harmiso HGG Adv 2025 1
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy [PMID:32686621] Richard P, Feng S, Tsai YL, Li W, Rinche Autophagy 2021 1
Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent D [PMID:31533039] Cristini A, Ricci G, Britton S, Salimben Cell Rep 2019 1
Molecular characterization of recessively inherited ataxic and neuropathic disor [PMID:41606223] ["Aslam F", "Wajid M", "Butt A", "Wohler Scientific reports 2026 0
Deciphering ALS-linked genetic variants in indian patients using targeted and ex [PMID:41137727] ["Reza S", "Handique J", "Sharma P", "Ma Amyotrophic lateral sclerosis 2026 0
Genetic commonalities between rare subtypes of ALS and CMT: insights into molecu [PMID:41621017] Aynaashe A, Kursula P Amino acids 2026 0
N(6)-methyladenosine modification of RNA is regulated by senataxin and E6 to con [PMID:41518615] ["Templeton C", "Laimins L"] Cell reports 2026 0
The SMC5/SMC6 complex is critical for resolving R-loop-induced transcription-rep [PMID:41533569] Wu T, Li Y, Zhao Y, Bournique E, Ortega Nucleic acids research 2026 0
Resolution of R-loops and transcription-replication conflicts by SETX-BRCA1-BARD [PMID:41917467] Dutta A, Ji JH, Syed S, Fang Q, Mukhopad Nature structural & molecular 2026 0
Ataxia and oculomotor apraxia caused by a large-scale deletion in the senataxin [PMID:40830689] ["Rusecka J", "Kierdaszuk B", "St\u0119p Journal of applied genetics 2025 0
Unraveling the genetic landscape of ALS in Greece: identification of known and n [PMID:41196070] ["Kartanou C", "Kontogeorgiou Z", "Loupi Amyotrophic lateral sclerosis 2025 0
Break-induced replication is activated to repair R-loop-associated double-strand [PMID:40475435] ["Wu T", "Li Y", "Shi L", "Wu X"] bioRxiv : the preprint server 2025 0
A role for human senataxin in contending with pausing and backtracking during tr [PMID:41232527] Han Z, Fu S, Johansen JV, Lopez Martinez Molecular cell 2025 0
Break-induced replication is activated to repair R-loop-associated double-strand [PMID:41037402] Wu T, Li Y, Zhao Y, Shah SB, Shi LZ, Wu Cell reports 2025 0
Unveiling ten novel SETX mutations: implications for ALS pathogenesis and clinic [PMID:40338003] ["Chen X", "Chen X", "Lin X", "Zhou W", Somatosensory & motor research 2025 0
ZPR1 Is Dispensable for HPV R-Loop Resolution but Regulates Host R-Loop Dynamics [PMID:41305523] Moffitt R, Brooks S, Androphy EJ, DeSmet Viruses 2025 0
Senataxin: A key actor in RNA metabolism, genome integrity and neurodegeneration [PMID:37558082] ["Giannini M", "Porrua O"] Biochimie 2024 0
Role of senataxin in R-loop-mediated neurodegeneration. [PMID:39070547] Kannan A, Gangadharan Leela S, Branzei D Brain communications 2024 0
Helicases in R-loop Formation and Resolution. [PMID:37778731] Yang S, Winstone L, Mondal S, Wu Y The Journal of biological chem 2023 0
R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response. [PMID:36544021] Crossley MP, Song C, Bocek MJ, Choi JH, Nature 2023 0
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