Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Sensory gating: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| α7 nAChR agonists | activates | drug | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Prefrontal sensory gating circuit restoration via PV interne | 0.775 | alzheimers | Circuit-level neural dynamics in neurode |
Scientific analyses that reference this entity
methodology | 2026-04-04 | 7 hypotheses Top: 0.512
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| CHI3L1 variant association with AD progression in human patients | exploratory | Alzheimer's disease | 0.850 | 0.00 | human patients | proposed | N/A |
| Brain Connectivity-Targeted tACS Trial in Early AD | clinical | Alzheimer's Disease | 0.509 | 0.50 | human postmortem brain tissue | proposed | $520,000 |
| s:** - Test whether HCN1 knockout specifically in EC layer II accelera | falsification | Alzheimer's Disease | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Positive Indiv | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| AD Combination Therapy Trial: Anti-Aβ + Anti-Tau | clinical | Alzheimer's Disease | 0.400 | 0.50 | cell_line | proposed | $180,000 |
| Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| tACS Connectivity Trial in Early Alzheimer's | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Brain Connectivity-Targeted tACS Trial in Early AD | clinical | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $730,000 |
| Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Res | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Long | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Integrated multimodal cell atlas of Alzheimer’s disease [PMID:39402379] | Gabitto MI, Travaglini KJ, Rachleff VM, | Nature Neuroscience | 2024 | 225 |
| Transcriptional and functional profiles of muscarinic receptor-expressing neuron [PMID:41857244] | Tsolias A, Mojica CA, Yamani R, Khanna S | Communications biology | 2026 | 0 |
| Neurophysiological and neuropharmacological effects of melatonin MT2 receptors a [PMID:41571206] | ["Barzon B", "Marchiotto F", "Nasini S", | Biochemical pharmacology | 2026 | 0 |
| Enhanced interhemispheric functional connectivity in elderly anxiety patients wi [PMID:41656398] | ["Chang Y", "Liu M", "Liu Y", "Xie X", " | Scientific reports | 2026 | 0 |
| Convergent transcriptomic and connectomic controllers of information integration [PMID:41606107] | Luppi AI, Uhrig L, Tasserie J, Mediano P | Nature human behaviour | 2026 | 0 |
| Transcranial direct current stimulation restores addictive behavior via prefront [PMID:41136747] | ["Zuo H", "Zhang W", "Wang L", "Wu Y", " | Molecular psychiatry | 2026 | 0 |
| Meta-Analyses of Auditory Evoked Potentials as Alzheimer Biomarkers. [PMID:40836165] | Bayat A, Mirmomeni G, Aiken S, Jafari Z | Ear and hearing | 2026 | 0 |
| Establishing mouse forebrain organoids as models of intrinsic cortical network a [PMID:41791384] | Hernandez S, Schweiger HE, Cline I, Kaur | Stem cell reports | 2026 | 0 |
| Altered Expression of GABA-Related Genes in Schizophrenia: Insights from Meta-An [PMID:41788138] | Singer Y, Yitzhaky A, Hertzberg L | Alpha psychiatry | 2026 | 0 |
| A silent Kv channel subunit shapes PV neuron action potential waveform and short [PMID:41632839] | Ganesh S, Canty TM, Sabatini BL | Proceedings of the National Ac | 2026 | 0 |
| Mitochondrial bioenergetic signatures differentiate asymptomatic from symptomati [PMID:41279752] | Mandal P, Trushina E, Arnold M, Kaddurah | bioRxiv : the preprint server | 2025 | 0 |
| Fate plasticity of interneuron specification. [PMID:40264797] | Mostajo-Radji MA, Leon WRM, Breevoort A, | iScience | 2025 | 0 |
| Multimodal Neuroimaging of Obesity: From Structural-Functional Mechanisms to Pre [PMID:40426616] | ["Liu W", "Li N", "Tang D", "Qin L", "Zh | Brain sciences | 2025 | 0 |
| Medial prefrontal cortex circuit dynamics involved in stage-specific addiction. [PMID:41307570] | ["Zhao D", "Zhang X", "Bai J"] | Brain structure & function | 2025 | 0 |
| Studies in rats of a target specific and reversible general anesthetic with a fa [PMID:41187127] | ["Xie Z", "Fong R", "Fox A"] | PloS one | 2025 | 0 |
| tDCS-induced enhancement of cognitive flexibility in autism: role of frontal lob [PMID:40874060] | ["Han Y", "Dong A", "Xia C", "Zhang Z", | Frontiers in behavioral neuros | 2025 | 0 |
| Fate plasticity of interneuron specification. [PMID:40264797] | ["Mostajo-Radji M", "Leon W", "Breevoort | iScience | 2025 | 0 |
| The thalamic reticular nucleus orchestrates social memory. [PMID:38701789] | Wang F, Sun H, Chen M, Feng B, Lu Y, Lyu | Neuron | 2024 | 0 |
| A vagal reflex evoked by airway closure. [PMID:38448588] | ["Schappe M", "Brinn P", "Joshi N", "Gre | Nature | 2024 | 0 |
| Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379] | Gabitto MI, Travaglini KJ, Rachleff VM, | Nat Neurosci | 2024 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning Sensory gating in their description or question text
No additional research found