Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Synthetic biology / chemogenetics: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| CNO | participates_in | gene | 0.41 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Synthetic Biology Rewiring via Orthogonal Receptors | 0.420 | neurodegeneration | Microglia-astrocyte crosstalk amplificat |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.521
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Experiment Scoring Methodology | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| AAV-LRRK2 Gene Therapy IND-Enabling Study Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| AAV-LRRK2 IND-Enabling Study Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Proposed experiment from debate on Microglia activate astrocytes via I | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Current and future advances in practice: SAPHO syndrome and chronic non-bacteria [PMID:39411288] | Furer V, Kishimoto M, Tomita T, Elkayam | Rheumatol Adv Pract | 2024 | 1 |
| NMR-based isotopic and isotopomic analysis. [PMID:33198965] | Akoka S, Remaud GS | Prog Nucl Magn Reson Spectrosc | 2020 | 1 |
| Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid n [PMID:32632286] | Nagai Y, Miyakawa N, Takuwa H, Hori Y, O | Nat Neurosci | 2020 | 1 |
| Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progres [PMID:30814274] | Runegaard AH, Fitzpatrick CM, Woldbye DP | Pharmacol Rev | 2019 | 1 |
| The Utilization of Robotic Pets in Dementia Care. [PMID:27716673] | Petersen S, Houston S, Qin H, Tague C, S | J Alzheimers Dis | 2017 | 1 |
| Chemogenetic Modulation of Astrocytic Activity Rescues Hippocampus Associated Ne [PMID:41089460] | ["Gerasimov E", "Berg M", "Bolshakova A" | Neural plasticity | 2025 | 0 |
| Chemogenetic Tools and their Use in Studies of Neuropsychiatric Disorders. [PMID:38957949] | Neřoldová M, Stuchlík A | Physiological research | 2024 | 0 |
| Clozapine-N-oxide protects dopaminergic neurons against rotenone-induced neuroto [PMID:38182072] | Sun Q, Wang Y, Hou L, Li S, Hong JS, Wan | Free radical biology & medicin | 2024 | 0 |
| Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice. [PMID:36892930] | ["Traut J", "Mengual J", "Meijer E", "Mc | eLife | 2023 | 0 |
| To Be or No B2: A Rare Cause of Stridor and Weakness in a Toddler. [PMID:34395718] | ["Frederick A", "Yang J", "Schneider S", | Child neurology open | 2021 | 0 |
| Fragment Database FDB-17. [PMID:28375006] | Visini R, Awale M, Reymond JL | Journal of chemical informatio | 2017 | 0 |
| Clozapine metabolites protect dopaminergic neurons through inhibition of microgl [PMID:27184631] | ["Jiang L", "Wu X", "Wang S", "Chen S", | Journal of neuroinflammation | 2016 | 0 |
Multi-agent debates referencing this entity