gene

TACI

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TACI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

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Summary

The TNFRSF13B gene encodes TACI ( Transmembrane Activator and Calcium Modulator), a critical receptor in B cell function, immune homeostasis, and neuroinflammation relevant to neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	TACI
Aliases	Transmembrane Activator and Calcium Modulator, TNFRSF13B
Chromosome	17p11.2
Protein Family	TNF Receptor Superfamily
Protein Type	Receptor
Function	is a type I transmembrane receptor belonging to the tumor necrosis factor receptor superfamily (TNFRSF).
Molecular Weight	32.5 kDa
Amino Acids	295 aa
Pathways	NF-κB, MAPK, PI3K
UniProt ID	O14836
GeneCards	TACI
Human Protein Atlas	TACI
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TACI — AlphaFold O14836 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TACI Protein (Transmembrane Activator and Calcium Modulator)

protein · 999 words

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TACI Gene (TNFRSF13B)

gene · 1942 words

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Pathway Diagram

graph TD
    TACI["TACI"]
    neurodegeneration["neurodegeneration"]
    TACI -->|"implicated_in"| neurodegeneration
    style TACI fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TACI in their description or question text

No additional research found