Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TACR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | TACR1 |
| Full Name | Tachykinin Receptor 1 |
| Chromosome | 2p12 |
| Function | NK1 receptor antagonists may have cognitive-enhancing effects |
| Primary Expression | the central and peripheral nervous systems and plays important roles in pain transmission, neuroinflammation, mood regulation, and stress responses[@h |
| Pathways | MAPK |
| GeneCards | TACR1 |
| Human Protein Atlas | TACR1 |
| Extracellular N-terminus | Contains ligand-binding sites |
| Transmembrane domains | Seven alpha-helices spanning the membrane |
| Intracellular C-terminus | Couples to G proteins and contains phosphorylation sites |
| Ligand binding | High affinity for substance P (SP), with lower affinity for neurokinin A and B |
| Gαq/11 | Activates phospholipase C (PLC) |
| IP3 production | Leads to intracellular Ca2+ release |
| DAG formation | Activates protein kinase C (PKC) |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TACR1["TACR1"]
neurodegeneration["neurodegeneration"]
TACR1 -->|"implicated_in"| neurodegeneration
style TACR1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TACR1 in their description or question text
No additional research found