Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TAM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| GAS6/TAM receptor complex | co_associated_with | gene | 0.30 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.513
neuroinflammation | 2026-04-13 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Gandouling protection against brain injury in Wilson's disease via SIR | validation | Hepatolenticular degeneration | 0.900 | 0.00 | TX mice (Wilson's disease mode | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| TGM2 and implications for human disease: role of alternative splicing. [PMID:23276939] | Lai TS, Greenberg CS | Front Biosci (Landmark Ed) | 2013 | 1 |
| Transglutaminase 2 modulates inflammatory angiogenesis via vascular endothelial [PMID:40619121] | Zhou G, Zhang M, Zheng S, Yang G, Li L e | J Adv Res | 2026 | 0 |
| The Search for a Universal Treatment for Defined and Mixed Pathology Neurodegene [PMID:39769187] | O'Day DH | International journal of molec | 2024 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| Calmodulin Binding Domains in Critical Risk Proteins Involved in Neurodegenerati [PMID:36421678] | ["O'Day D"] | Current issues in molecular bi | 2022 | 0 |
| Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulati [PMID:32704090] | Lee HJ, Jung YH, Choi GE | Cell Death Differ | 2021 | 0 |
| Engineering complex communities by directed evolution. [PMID:33986540] | Chang CY, Vila JCC, Bender M, Li R, Mank | Nature ecology & evolution | 2021 | 0 |
| Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100] | Tajika T, Kuboi T, Endo F, Hatori Y, Sai | Progress in rehabilitation med | 2021 | 0 |
| Dietary Gluten and Neurodegeneration: A Case for Preclinical Studies. [PMID:32751379] | Mohan M, Okeoma CM, Sestak K | International journal of molec | 2020 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.74 · 2026-04-16
closed · Rounds: 4 · Score: 0.75 · 2026-04-15
Hypotheses and analyses mentioning TAM in their description or question text
Score: 0.513 · neuroinflammation · 2026-04-14
## Mechanistic Overview GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to Reduce Neuroinflammatory Cell Infiltr
Score: 0.490 · neurodegeneration · 2026-04-25
Aβ leaves astrocytes in a reactive, low-EAAT2 state that increases extrasynaptic NMDA receptor drive, allowing dendritic
Score: 0.000 · unknown disease · 2026-04-28
Engineered RNA aptamers could selectively recruit neuroprotective proteins to existing 53BP1 condensates, creating thera
Score: 0.000 · unknown disease · 2026-04-28
Selective mGluR5 positive allosteric modulators to stabilize sleep-wake cycles by enhancing glutamatergic signaling duri