gene

TARS

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about TARS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

TARS1 — Threonyl-tRNA Synthetase 1

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🧬 Gene Info

Gene Symbol	TARS1
Full Name	Threonyl-tRNA Synthetase 1
Aliases	ThrRS
Function	TARS1 (Threonyl-tRNA Synthetase 1) is a human gene encoding threonyl-tRNA synthetase (ThrRS), an essential aminoacyl-tRNA synthetase that catalyzes the attachment of threonine to its cognate tRNA.
Amino Acids	724 aa
GeneCards	TARS1
Human Protein Atlas	TARS1
N-terminal domain	Contains the editing site that clears mischarged amino acids
Core catalytic domain	Class II synthetase fold with the characteristic KMSKS loop
C-terminal domain	Involved in dimerization and extra-translational functions
Appendage domains	Include sequences for nuclear localization and protein-protein interactions
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TARS1 — Threonyl-tRNA Synthetase 1

gene · 1422 words

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Pathway Diagram

graph TD
    TARS["TARS"]
    neurodegeneration["neurodegeneration"]
    TARS -->|"implicated_in"| neurodegeneration
    style TARS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning TARS in their description or question text

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