Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TDP, LATE, AD, RNA, SEA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TDP-43 Pathology Creates a Distinct Epigenetic Clock "Signat | 0.483 | - | Epigenetic clocks as biomarkers for Alzh |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| TDP-43 seeding induces cytoplasmic aggregation heterogeneity and nuclear loss of [PMID:40157356] | ["Rummens Jens", "Khalil Bilal", "Y\u013 | Neuron | 2025 | 0 |
| TDP-43 seeding induces cytoplasmic aggregation heterogeneity and nuclear loss of [PMID:40157356] | ["Rummens Jens", "Khalil Bilal", "Y\u013 | Neuron | 2025 | 0 |
| The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not [PMID:38079474] | Zibold, Lessard, Picard, da Silva, Zador | Brain : a journal of neurology | 2024 | 0 |
| TDP-43 nuclear condensation and neurodegenerative proteinopathies. [PMID:39327159] | Vassallu, Igaz | Trends in neurosciences | 2024 | 0 |
| TDP-43 nuclear condensation and neurodegenerative proteinopathies. [PMID:39327159] | Unknown | Trends in neurosciences | 2024 | 0 |
| The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not [PMID:38079474] | Unknown | Brain : a journal of neurology | 2024 | 0 |
| Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and ag [PMID:35112738] | Gruijs da Silva LA, Simonetti F, Hutten | The EMBO journal | 2022 | 0 |
| Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and ag [PMID:35112738] | Gruijs da Silva LA, Simonetti F, Hutten | The EMBO journal | 2022 | 0 |
| FUS and TDP-43 Phases in Health and Disease. [PMID:33446423] | ["Portz Bede", "Lee Bo Lim", "Shorter Ja | Trends in biochemical sciences | 2021 | 0 |
| FUS and TDP-43 Phases in Health and Disease. [PMID:33446423] | ["Portz Bede", "Lee Bo Lim", "Shorter Ja | Trends in biochemical sciences | 2021 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TDP, LATE, AD, RNA, SEA in their description or question text
No additional research found