gene

TGFRB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TGFRB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

TGFBR1 — Transforming Growth Factor Beta Receptor 1

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🧬 Gene Info

Gene Symbol	TGFBR1
Full Name	Transforming Growth Factor Beta Receptor 1
Chromosome	9q22.33
Protein Type	Receptor
Function	is a critical component of TGF-beta signaling in the nervous system.
Primary Expression	cerebral blood vessels[@nitta2019]
UniProt ID	P36897
NCBI Gene ID	7046
Ensembl ID	ENSG00000106799
OMIM	191181
GeneCards	TGFBR1
Human Protein Atlas	TGFBR1
Extracellular domain	Contains cysteine-rich regions that mediate ligand binding
Transmembrane domain	Single-pass transmembrane helix
TGF-beta signal initiation	Primary mediator of TGF-beta1, TGF-beta2, and TGF-beta3 signaling[@gordon2020]
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TGFRB1 — AlphaFold P36897 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TGFBR1 — Transforming Growth Factor Beta Receptor 1

gene · 954 words

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Pathway Diagram

graph TD
    TGFRB1["TGFRB1"]
    neurodegeneration["neurodegeneration"]
    TGFRB1 -->|"implicated_in"| neurodegeneration
    style TGFRB1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning TGFRB1 in their description or question text

No additional research found