gene

TGFRB2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about TGFRB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

TGFBR2 — Transforming Growth Factor Beta Receptor 2

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🧬 Gene Info

Gene Symbol	TGFBR2
Full Name	Transforming Growth Factor Beta Receptor 2
Chromosome	3p24.1
Protein Type	Receptor
Function	is an essential component of TGF-beta signaling in the nervous system.
Primary Expression	cerebral blood vessels, critical for BBB function[@nitta2019]
UniProt ID	P37173
NCBI Gene ID	7048
Ensembl ID	ENSG00000163513
OMIM	190182
GeneCards	TGFBR2
Human Protein Atlas	TGFBR2
Extracellular domain	Contains TGF-beta binding regions that recognize ligand-bound type III receptors
Transmembrane domain	Single-pass transmembrane helix
TGF-beta signal initiation	Primary receptor for TGF-beta1, TGF-beta2, and TGF-beta3[@gordon2020]
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TGFRB2 — AlphaFold P37173 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TGFBR2 — Transforming Growth Factor Beta Receptor 2

gene · 943 words

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Pathway Diagram

graph TD
    TGFRB2["TGFRB2"]
    neurodegeneration["neurodegeneration"]
    TGFRB2 -->|"implicated_in"| neurodegeneration
    style TGFRB2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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