Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TIMD4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Gene Symbol | TIMD4 |
| Full Name | TIMD4 (T Cell Immunoglobulin and Mucin Domain Containing 4) |
| Aliases | T Cell Immunoglobulin and Mucin Domain Containing 4 |
| Chromosome | 5q33.3 |
| Protein Type | Gene |
| Function | The TIMD4 gene encodes TIM-4 (T-cell immunoglobulin and mucin domain-containing protein 4), a phosphatidylserine receptor that plays a critical role in the recognition and engulfment of apoptotic cell |
| UniProt ID | Q9C0J8 |
| NCBI Gene ID | 10578 |
| Ensembl ID | ENSG00000134030 |
| GeneCards | TIMD4 |
| Human Protein Atlas | TIMD4 |
| Apoptotic Cell Clearance | TIMD4 mediates the engulfment of dying cells, preventing the release of intracellular contents that could trigger inflammatory responses [@phosphatidylserine] |
| Immune Tolerance | Proper clearance of apoptotic cells by TIMD4-expressing phagocytes prevents autoimmunity |
| Resolution of Inflammation | TIMD4 contributes to the anti-inflammatory environment during tissue repair |
| Synaptic Pruning | During development, microglia use TIMD4 to recognize and eliminate excess synapses |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TIMD4["TIMD4"]
neurodegeneration["neurodegeneration"]
TIMD4 -->|"implicated_in"| neurodegeneration
style TIMD4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TIMD4 in their description or question text
No additional research found