TIMM13

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIMM13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

TIMM13 (Translocase of Inner Mitochondrial Membrane Subunit 13) is a small mitochondrial intermembrane space protein that functions as part of the small TIM chaperone complex. It facilitates the import of hydrophobic proteins across the mitochondrial intermembrane space and is implicated in Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions.

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graph TD
    TIMM13["TIMM13
TIM13 Chaperone"]
    
    subgraph TIMComplex["Small TIM Chaperone Complex"]
        TIMM8["TIMM8A/B"]
        Complex["TIM8-TIM13
Hexameric Complex"]
    end
    
    subgraph ImportMachinery["Mitochondrial Import Machinery"]
        TOM["TOM Complex
(Outer Membrane)"]
        TIM22["TIM22 Complex
(Inner Membrane)"]
        TIM23["TIM23 Complex
(Inner Membrane)"]
    end
    
    subgraph Substrates["Import Substrates"]
        Carriers["Metabolite Carriers"]
        TimSubunits["TIM Subunits"]
        Hydrophobic["Hydrophobic
Proteins"]
    end
    
    subgraph Function["Cellular Functions"]
        MitoImport["Protein Import"]
        IMS["IMS Chaperoning"]
        MitoBio["Mitochondrial
Biogenesis"]
    end
    
    subgraph Disease["Disease Associations"]
        AD["Alzheimer's Disease"]
        PD["Parkinson's Disease"]
        Neurodegeneration["Neurodegeneration"]
    end
    
    TIMM8 -->|"forms complex"| Complex
    TIMM13 -->|"forms complex"| Complex
    
    TOM -->|"translocates to"| Complex
    Complex -->|"delivers to"| TIM22
    Complex -->|"delivers to"| TIM23
    
    Complex -->|"chaperones"| Carriers
    Complex -->|"chaperones"| TimSubunits
    Complex -->|"chaperones"| Hydrophobic
    
    TIMM13 -->|"enables"| MitoImport
    TIMM13 -->|"performs"| IMS
    TIMM13 -->|"supports"| MitoBio
    
    TIMM13 -.->|"implicated in"| AD
    TIMM13 -.->|"implicated in"| PD
    TIMM13 -.->|"dysfunction causes"| Neurodegeneration
    
    classDef mainProtein fill:#ff6b6b,stroke:#c92a2a,stroke-width:3px,color:#e0e0e0,font-size:14px
    classDef complex fill:#4ecdc4,stroke:#0d9488,stroke-width:2px,color:#e0e0e0
    classDef machinery fill:#a8e6cf,stroke:#38ada9,stroke-width:2px,color:#e0e0e0
    classDef substrate fill:#ffe66d,stroke:#f39c12,stroke-width:2px,color:#e0e0e0
    classDef function fill:#95e1d3,stroke:#38ada9,stroke-width:2px,color:#e0e0e0
    classDef disease fill:#ff9999,stroke:#d9534f,stroke-width:2px,color:#e0e0e0
    
    class TIMM13 mainProtein
    class TIMM8,Complex complex
    class TOM,TIM22,TIM23 machinery
    class Carriers,TimSubunits,Hydrophobic substrate
    class MitoImport,IMS,MitoBio function
    class AD,PD,Neurodegeneration disease

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