Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TIMM8A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | TIMM8A |
| Full Name | Translocase of Inner Mitochondrial Membrane Subunit 8A |
| Chromosome | Xq22.1 |
| Protein Family | Small TIM family |
| Protein Type | Chaperone |
| Function | is a small mitochondrial chaperone protein located in the mitochondrial intermembrane space (IMS) that plays a critical role in the import of nuclear-encoded proteins into mitochondria [@koehler1998]. |
| Molecular Weight | ~9.7 kDa |
| Amino Acids | 97 aa |
| UniProt ID | O60220 |
| NCBI Gene ID | 10578 |
| Ensembl ID | ENSG00000126945 |
| OMIM | 300356 (gene), 304700 (MTS) |
| GeneCards | TIMM8A |
| Human Protein Atlas | TIMM8A |
| Previous Symbols | TIM8A, DDP, DFNX6 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["TIMM8A"]
N1["ICE1"]
N0 -->|"interacts with"| N1
N2["neurodegeneration"]
N0 -->|"implicated in"| N2
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||