Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TLR10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | TLR10 |
| Full Name | Toll-Like Receptor 10 |
| Chromosome | 4p14 |
| Protein Type | Receptor |
| Function | is a type I transmembrane pattern recognition receptor belonging to the TLR1/2/6/10 subfamily. |
| Ensembl ID | ENSG00000150045 |
| GeneCards | TLR10 |
| Human Protein Atlas | TLR10 |
| Co-receptor function | Acts primarily as a co-receptor rather than a primary pattern recognition receptor |
| Modulatory effects | Can inhibit signaling from TLR2-containing heterodimers |
| Adaptive immunity | Involved in B cell responses and antibody production |
| Brain expression | Present in microglia and other brain cells |
| LRR 3 | Contains an insertion unique among TLRs |
| TIR domain | Has specific residues that affect signaling |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TLR10["TLR10"]
neurodegeneration["neurodegeneration"]
TLR10 -->|"implicated_in"| neurodegeneration
style TLR10 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| No outgoing edges | |||
| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TLR10 in their description or question text
No additional research found