Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TMPRSS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | TMPRSS2 |
| Pathways | Sars-Cov-2 Infection |
| GeneCards | TMPRSS2 |
| Human Protein Atlas | TMPRSS2 |
| Associated Diseases | SARS-CoV-2 |
| Interactions | ACE2, FCGRT, SARS |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TMPRSS2["TMPRSS2"] -->|"involved in"| SARS_CoV_2["SARS-CoV-2"]
style SARS_CoV_2 fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
TMPRSS2["TMPRSS2"] -->|"involved in"| Sars_Cov_2_Infection["Sars-Cov-2 Infection"]
style Sars_Cov_2_Infection fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
TMPRSS2["TMPRSS2"] -->|"protects against"| ALS["ALS"]
style ALS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
TMPRSS2["TMPRSS2"] -->|"protects against"| AND["AND"]
style AND fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
TMPRSS2["TMPRSS2"] -->|"protects against"| FCGRT["FCGRT"]
style FCGRT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
TMPRSS2["TMPRSS2"] -->|"protects against"| Rb["Rb"]
style Rb fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
ACE2["ACE2"] -->|"protects against"| TMPRSS2["TMPRSS2"]
style ACE2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
FCGRT_1["FCGRT"] -->|"protects against"| TMPRSS2["TMPRSS2"]
style FCGRT_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
SARS["SARS"] -->|"interacts"| TMPRSS2["TMPRSS2"]
style SARS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
style TMPRSS2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| SARS-CoV-2 | associated_with | entity | 0.90 |
| Sars-Cov-2 Infection | involved_in | process | 0.90 |
| SARS-CoV-2 | activates | entity | 0.80 |
| ALS | protects_against | disease | 0.65 |
| Als | protects_against | disease | 0.65 |
| AND | protects_against | gene | 0.60 |
| FCGRT | protects_against | gene | 0.60 |
| Rb | protects_against | protein | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||