Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TNFAIP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TNFα-induced protein involved in cell proliferation, apoptosis regulation, and inflammatory responses. Also known as BAP1 - BRCA1 associated protein 1.
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| Gene Symbol | TNFAIP1 |
| Full Name | TNF Alpha Induced Protein 1 (BAP1) |
| Chromosome | 3p21.1 |
| Function | is a multifunctional protein that plays critical roles in cell proliferation, apoptosis regulation, and inflammatory responses [1]. |
| Amino Acids | 729 aa |
| Exons | 16 |
| Pathways | NF-κB |
| UniProt ID | [Q15118](https://www.uniprot.org/uniprot/Q15118) |
| Ensembl ID | ENSG00000106526 |
| OMIM | 607293 |
| GeneCards | TNFAIP1 |
| Human Protein Atlas | TNFAIP1 |
| Deubiquitinase (DUB) activity | Removes ubiquitin from target proteins |
| UCH activity | Specifically cleaves ubiquitin from the C-terminus of proteins |
| Cell cycle arrest | Promotes G1/S checkpoint arrest |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TNFAIP1["TNFAIP1"]
neurodegeneration["neurodegeneration"]
TNFAIP1 -->|"implicated_in"| neurodegeneration
style TNFAIP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TNFAIP1 in their description or question text
No additional research found