TNFAIP3

protein-coding External Resolution
GeneCards NCBI PubMed

External Info (via mygene)

SymbolTNFAIP3
NameTNF alpha induced protein 3
Typeprotein-coding
Sourcemygene

Summary

This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been

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