gene

TNFAIP8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFAIP8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	TNFAIP8
Full Name	TNF Alpha Induced Protein 8 (SCC-S2)
Chromosome	5q23.2
Function	### Apoptosis Regulation
Primary Expression	most tissues, with particularly high expression in hematopoietic cells and various tumors [3]
Amino Acids	198 aa
Exons	5
Pathways	NF-κB
UniProt ID	[Q8WXB1](https://www.uniprot.org/uniprot/Q8WXB1)
Ensembl ID	ENSG00000116329
OMIM	607314
GeneCards	TNFAIP8
Human Protein Atlas	TNFAIP8
NF-κB binding sites	Mediate TNF-α induced expression
p53 responsive elements	Connect to DNA damage responses
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TNFAIP8 — TNF Alpha Induced Protein 8 (SCC-S2)

gene · 1790 words

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TNFAIP8L1 — TNF Alpha Induced Protein 8 Like 1

gene · 1794 words

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Pathway Diagram

graph TD
    TNFAIP8["TNFAIP8"]
    neurodegeneration["neurodegeneration"]
    TNFAIP8 -->|"implicated_in"| neurodegeneration
    style TNFAIP8 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TNFAIP8 in their description or question text

No additional research found