Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TNFAIP8L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TNFAIP8 homolog involved in cell death regulation and inflammatory responses. May play roles in neuroprotection and cancer biology.
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| Gene Symbol | TNFAIP8L1 |
| Full Name | TNF Alpha Induced Protein 8 Like 1 |
| Chromosome | 1p35.2 |
| Function | is a member of the TNFAIP8 family of proteins that play important roles in cell death regulation, inflammatory responses, and cellular homeostasis [1]. |
| Primary Expression | various tissues, with particularly high expression in immune cells and neurons |
| Subcellular Localization | **Acetylation**: May regulate protein function |
| Amino Acids | 199 aa |
| Exons | 4 |
| Pathways | NF-κB |
| UniProt ID | [Q8WXD0](https://www.uniprot.org/uniprot/Q8WXD0) |
| Ensembl ID | ENSG00000134852 |
| OMIM | 612569 |
| GeneCards | TNFAIP8L1 |
| Human Protein Atlas | TNFAIP8L1 |
| NF-κB binding sites | Mediate TNF-α induced expression |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TNFAIP8L1["TNFAIP8L1"]
neurodegeneration["neurodegeneration"]
TNFAIP8L1 -->|"implicated_in"| neurodegeneration
style TNFAIP8L1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TNFAIP8L1 in their description or question text
No additional research found