gene

TNFRSF13B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFRSF13B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

1Outgoing

0Incoming

0Experiments

0Debates

Summary

TACI Gene (TNFRSF13B)

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🧬 Gene Info

Gene Symbol	TACI
Full Name	Transmembrane Activator and Calcium Modulator
Aliases	Transmembrane Activator and Calcium Modulator, TNFRSF13B
Chromosome	17p11.2
Protein Family	TNF Receptor Superfamily
Protein Type	Receptor
Function	is a type I transmembrane receptor belonging to the tumor necrosis factor receptor superfamily (TNFRSF).
Molecular Weight	32.5 kDa
Amino Acids	295 aa
Pathways	NF-κB, MAPK, PI3K
UniProt ID	O14836
GeneCards	TACI
Human Protein Atlas	TACI
ERK pathway	Promotes cell proliferation and survival
p38 pathway	Involved in stress responses and cytokine production
Associated Diseases	Antibody Deficiency
KG Connections	1 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TNFRSF13B — AlphaFold O14836 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TACI Gene (TNFRSF13B)

gene · 1942 words

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Pathway Diagram

graph TD
    TNFRSF13B["TNFRSF13B
(TACI receptor)"]
    BAFF["BAFF
(B-cell activating factor)"]
    APRIL["APRIL
(A proliferation-inducing ligand)"]
    B_cell_survival["B-cell survival
and proliferation"]
    Antibody_production["Antibody production"]
    Antibody_deficiency["Antibody Deficiency"]
    CNS_inflammation["CNS inflammation"]
    Microglial_activation["Microglial activation"]
    BBB_dysfunction["Blood-brain barrier
dysfunction"]
    Neuronal_damage["Neuronal damage"]
    Neurodegeneration["Neurodegeneration"]
    Complement_activation["Complement activation"]
    Autoantibodies["Autoantibodies
production"]
    Immune_dysregulation["Immune dysregulation"]
    
    BAFF -->|"binds"| TNFRSF13B
    APRIL -->|"binds"| TNFRSF13B
    TNFRSF13B -->|"promotes"| B_cell_survival
    B_cell_survival -->|"enhances"| Antibody_production
    TNFRSF13B -->|"deficiency causes"| Antibody_deficiency
    Antibody_deficiency -->|"leads to"| Immune_dysregulation
    Immune_dysregulation -->|"triggers"| CNS_inflammation
    CNS_inflammation -->|"activates"| Microglial_activation
    Microglial_activation -->|"damages"| BBB_dysfunction
    BBB_dysfunction -->|"promotes"| Neuronal_damage
    Neuronal_damage -->|"results in"| Neurodegeneration
    Immune_dysregulation -->|"promotes"| Autoantibodies
    Autoantibodies -->|"activates"| Complement_activation
    Complement_activation -->|"enhances"| Neuronal_damage
    
    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#fff
    
    class TNFRSF13B central
    class B_cell_survival,Antibody_production protective
    class CNS_inflammation,Microglial_activation,BBB_dysfunction,Neuronal_damage,Complement_activation,Autoantibodies,Immune_dysregulation pathological
    class BAFF,APRIL regulatory
    class Antibody_deficiency,Neurodegeneration disease

Outgoing (1)

Target	Relation	Type	Str
Antibody Deficiency	associated_with	disease	0.80

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TNFRSF13B in their description or question text

No additional research found